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Friday, March 8, 2013

CISPLATIN: Invention of an Anticancer Drug

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CISPLATIN - CISTIN

Cisplatin is best known anticancer drug. Cisplatin chemotherapy recognised for lengthening of survival for some common types of lung cancer.
Cisplatin represents today one of the most successful drugs in chemotherapy.




Cisplatin is a tiny little drug molecule that contains a platinum ion in the middle of a flat square with two chloride ions and two ammonia molecules making up the corners. Approved for use in humans in 1978, it was the first of a completely new type of anticancer drug and remains an extremely effective and common treatment for conditions such as testicular and ovarian cancer.

When cisplatin gets into the body, its neutral overall charge means that it can cross the cell membrane. Once in a cell it becomes activated by the replacement of one of the chlorides by a water molecule. The chloride falls off because the concentration of chloride within a cell is much less than it is in the bloodstream. The water itself is, in turn, easily displaced by the basic nitrogen atoms on DNA, specifically on a guanine nucleobase. Once bound to DNA the second chloride ion is replaced by a guanine nitrogen atom from an adjacent DNA strand.


Cisplatin Concept Map:




Cisplatin went through several phases of testing before it was approved by the Food and Drug Administration (FDA) for use in the United States.

Cisplatin is administered intravenously as short-term infusion in normal saline for treatment of solid malignancies. It is used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas, and germ cell tumors. Cisplatin is particularly effective against testicular cancer; the cure rate was improved from 10% to 85%.

Cisplatin saved countless lives. Its available in tablet form as well as Injection. There are many brands available in market.

17 comments:

  1. I have been suffering from HIV/AIDS disease for the last five years and had constant pain, especially in my body. During the first year,I had faith in God that i would be healed someday.This disease started circulate all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (Herpes virus and Cancer) by this Man Dr. SUKU and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so i wrote to Dr SUKU telling him about my HIV/AIDS he told me not to worry that i was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as the Dr SUKU assured me that i have cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was true, So friends my advise is if you have such sickness disease, HERPES CURE OR CANCER OR HPV CURE,HIV&AIDS, or any other at all you can email Dr SUKU on:greatsukusolutiontemple@hotmail.com you call him telephone:+234874839242 get your healing now and be free from cancer Here is him email:greatsukusolutiontemple@hotmail.com.

    ReplyDelete
    Replies
    1. I am very happy today with my family. My name is lisa tommy living in USA, My husband left me for a good 3 years now, and i love him so much, i have been looking for a way to get him back since then. i have tried many options but he did not come back, until i met a friend that darted me to Dr.Jato a spell caster, who helped me to bring back my husband after 2 weeks. Me and my husband are living happily together today, That man is great, you can contact him via email jatolovespell@gmail.com Now i will advice any serious persons that found themselves in this kind of problem to contact him now a fast solution without stress.. He always hello, now i call him my father.contact him now he is always online email (jatolovespell@gmail.com) or contact him on his whatsapp mobile line +2348140033827...

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    2. Hello viewers I am glad to have met with the powerful herbal healer called
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    3. WOW!! This is the most wonderful thing i have ever experience and i need to share this great testimony..I visited a forum here on the internet on the 8TH MATCH 2020, And i saw a marvelous testimony of this powerful and great spell caster called Dr voodoo on the forum..I never believed it, because i never heard or learn anything about magic before.. No body would have been able to convince me about magical spells, not until Dr voodoo did a marvelous work for me and restored my marriage of 6 years back to me and brought my spouse back to me in the same 24 hours just as i read on the internet..i was truly flabbergasted and shocked when my husband kneel down begging for forgiveness and for me to accept him back.. I am really short of words and joy, and i don't know how much to convey my appreciation to you Dr voodoo you are a God sent to me and my entire family.. And now i am a joyful woman once again.. here is his email voodoospelltemple66@gmail.com you can also add Dr.voodoo on whatsApp +2348140120719

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  2. I have been suffering from HIV/AIDS disease for the last five years and had constant pain, especially in my body. During the first year,I had faith in God that i would be healed someday.This disease started circulate all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (Herpes virus and Cancer) by this Man Dr. SUKU and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so i wrote to Dr SUKU telling him about my HIV/AIDS he told me not to worry that i was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as the Dr SUKU assured me that i have cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was true, So friends my advise is if you have such sickness disease, HERPES CURE OR CANCER OR HPV CURE,HIV&AIDS, or any other at all you can email Dr SUKU on:greatsukusolutiontemple@hotmail.com you call him telephone:+234874839242 get your healing now and be free from cancer Here is him email:greatsukusolutiontemple@hotmail.com...

    ReplyDelete
    Replies
    1. Greetings to the general public, I want to tell about how I was cured of
      HIV disease by a Doctor called Dr. voodoo . I was browsing the Internet
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  3. I used to suffer from HERPES GENITAL for about 3 years so I can relate to people who have the cured. No medications or treatments ever really did anything for me (i tried them all no one work. but I was actually able to completely cure HERPES naturally after countless hours of online research. What worked for me is as follows: I saw Dr ILLUOBE Information online that he normally cure and treat disease and infirmities with his Herbal Medicine, I never really believed the people who where recommending him thou i saw on blog about 6 people where also testifying on how they were cured by Dr ILLUOBE,and still Ellen recommend Dr ILLUOBE who uses herbal medication to cure HERPES GENITAL VIRUS and gave me his email, so i mail him He told me all the things I need to do and also give me instructions to take, which I followed properly. Before I knew what is happening after two weeks the HERPES GENITAL VIRUS that was in my body got vanished . so if you are also heart broken and also need a help, you can also email him: drilluobe@live.com .. if you are infected with any disease like HIV, AIDS,CANCER, HERPES.PVC, or any other disease you can also be happy like me by contacting.....
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    I’m given you 100% grantee, soon as you have getting in touch with Dr.ILLUOBE your problems will be solved accurately.

    Thanks

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  6. i am very much delighted to every viewers that is reading this,i want to inform the whole public of how I got cured from herpes simplex virus, i was diagnosed of herpes since 3 years ago and also find out that my herpes virus also effected my lover,this Virus started circulating all over my body, and we have also taken treatment from our doctor, few weeks back i came on the net to see if i will be able to get any information as to cure this Virus, on my search i saw various testimony of someone who was healed from herpes simplex virus by the great man called Dr Agbaka and without any hesitation, i contact mail: agbakaherbalhome@gmail.com, i wrote him and and he guided me, i asked him for solutions and he started the remedies for me and indeed 2 weeks after i started using the medicine, i was completely cured no doubt was found on my body, so dear viewers why wasting your time living with this deadly Virus, you can contact him now for your disease,contact his Email agbakaherbalhome@gmail.com or you can call and whatsApp him on his mobile number +2348143502763

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  10. I am John Danilla from UK( northern ireland), i want to share a
    testimony on how a powerful spell caster cured my HIV disease, i was
    diagnosed of this disease, in the year 2009, last week i saw a testimony on
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    problems is over and then he decided to do an healing spell spell for me so
    after he finished it, he told me to wait for just 24 hours and then i
    should go for a test, so i really did as he had said, so my greatest
    surprised when i went to the hospital to go for an HIV test, the Medical
    doctor diagnosed that, i am now HIV negetative at first i was amazed and
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  12. I am very happy today with my family. My name is lisa tommy living in USA, My husband left me for a good 3 years now, and i love him so much, i have been looking for a way to get him back since then. i have tried many options but he did not come back, until i met a friend that darted me to Dr.Jato a spell caster, who helped me to bring back my husband after 2 weeks. Me and my husband are living happily together today, That man is great, you can contact him via email jatolovespell@gmail.com Now i will advice any serious persons that found themselves in this kind of problem to contact him now a fast solution without stress.. He always hello, now i call him my father.contact him now he is always online email (jatolovespell@gmail.com) or contact him on his whatsapp mobile line +2348140033827...

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  13. I am really happy that i have been cured from (HERPES SIMPLEX VIRUS) with the herbal medicine of Dr OSAGIE , i have been suffering from this disease for the past 3 years and 4 mouth without solution until i came across the email of this doctor who have cure so many people with his herbal medicine, i also choose to give him a chance to help me and my husband, he told me what to do and i kindly did it, and he gave us his herbal medicine and direct me on how to use it, i also follow his instructions for use and he ask us to go for a check up after 1 week and 5days which i did, to my greatest surprise our result came out as negative, we are really happy that there is someone like this doctor who is ready to help anytime any day. To all the readers and viewers that is doubting this testimony stop doubting it and contact this doctor if you really have one and see if he will not actually help you. i am not a stupid woman that i will come out to the public and start saying what someone have not done for me and i know that there are some people out there who are really suffering and hurting their family just because of these diseases so you can to mail him on drosagiesolutiontemple@gmail.com OR
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    HERPES SIMPLEX VIRUS.
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    CANCER
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    .HIV/AIDS
    Thank you for your time

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