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Friday, March 8, 2013

CISPLATIN: Invention of an Anticancer Drug

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CISPLATIN - CISTIN

Cisplatin is best known anticancer drug. Cisplatin chemotherapy recognised for lengthening of survival for some common types of lung cancer.
Cisplatin represents today one of the most successful drugs in chemotherapy.




Cisplatin is a tiny little drug molecule that contains a platinum ion in the middle of a flat square with two chloride ions and two ammonia molecules making up the corners. Approved for use in humans in 1978, it was the first of a completely new type of anticancer drug and remains an extremely effective and common treatment for conditions such as testicular and ovarian cancer.

When cisplatin gets into the body, its neutral overall charge means that it can cross the cell membrane. Once in a cell it becomes activated by the replacement of one of the chlorides by a water molecule. The chloride falls off because the concentration of chloride within a cell is much less than it is in the bloodstream. The water itself is, in turn, easily displaced by the basic nitrogen atoms on DNA, specifically on a guanine nucleobase. Once bound to DNA the second chloride ion is replaced by a guanine nitrogen atom from an adjacent DNA strand.


Cisplatin Concept Map:




Cisplatin went through several phases of testing before it was approved by the Food and Drug Administration (FDA) for use in the United States.

Cisplatin is administered intravenously as short-term infusion in normal saline for treatment of solid malignancies. It is used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas, and germ cell tumors. Cisplatin is particularly effective against testicular cancer; the cure rate was improved from 10% to 85%.

Cisplatin saved countless lives. Its available in tablet form as well as Injection. There are many brands available in market.

3 comments:

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  2. I have been suffering from HIV/AIDS disease for the last five years and had constant pain, especially in my body. During the first year,I had faith in God that i would be healed someday.This disease started circulate all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (Herpes virus and Cancer) by this Man Dr. SUKU and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so i wrote to Dr SUKU telling him about my HIV/AIDS he told me not to worry that i was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as the Dr SUKU assured me that i have cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was true, So friends my advise is if you have such sickness disease, HERPES CURE OR CANCER OR HPV CURE,HIV&AIDS, or any other at all you can email Dr SUKU on:greatsukusolutiontemple@hotmail.com you call him telephone:+234874839242 get your healing now and be free from cancer Here is him email:greatsukusolutiontemple@hotmail.com...

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